Evidently Healthy, but Dem Diagnose with Alzheimer’s?
⬇️ Pidgin ⬇️ ⬇️ Black American Slang ⬇️ English
Plenty folk believe say dem dey okay, but according to new standards, you fit diagnose dem with Alzheimer’s even if dem no dey show symptoms. 🧠
Di diagnosis of Alzheimer’s disease usually dey involve plenty process. Doctor go collect di person history, discuss symptoms, and give verbal and visual cognitive tests.
For inside some cases, dem fit do PET scan, MRI, or spinal tap to check if two proteins wey dey di brain – amyloid plaques and tau tangles – dey present, as dem dey link to Alzheimer’s.
All these fit change well-well if new standards wey di Alzheimer’s Association working group propose enter ground.
Dem plan to change di approach from defining di sickness by symptoms and behavior to defining am biologically – with biomarkers, wey be substances for body wey show say person get disease.
Dem draft guidelines, Revised Criteria for Diagnosis and Staging of Alzheimer’s Disease, dey call for one simple approach. This fit mean say blood test go fit show if amyloid dey present. Some clinics and doctor’s offices don already dey use this kind test.
“Person wey get amyloid for brain fit dey sick, whether dem dey show symptoms or not,” Dr. Clifford R. Jack Jr., di chair of di working group yan. “Di problem don dey exist for many years before symptoms show. Na science. E dey undebatable.”
But plenty pipo still dey argue against di idea to rely solely on biomarkers. Di American Geriatrics Society don call di proposed criteria “premature” and say many of di panel members get ties to pharmaceutical and biotechnology industries, wey fit cause conflict of interest.
Dem only begin dis matter five years afta dem issue di last guidelines for diagnosis because two major events bin force dem to make changes. 🔄
First, di amyloid blood tests show say dem dey highly accurate, less invasive than spinal taps, and far less expensive than brain scans. Plus, some drugs wey dey remove amyloid from di brain, like aducanumab (brand name: Aduhelm) and lecanemab (Leqembi), receive regulatory approval, although dis one dey bring plenty kasala.
Are these changes enough reason to diagnose healthy pipo with irreversible sickness based on blood test wey fit detect amyloid? E be like say some doctors don already dey receive such requests.
But e dey hard to know how many of those with amyloid for brain go eventually get dementia. Na only further research go fit provide better answers to dis matter.
For now, plenty doctors dey argue say di proposed guidelines still need plenty work before dem fit put am into practice. But one thing wey sure be say, if dis change happen, e fit lead to one new kain pandemic of Alzheimer’s disease. 🧬🚫
NOW IN BLACK AMERICAN SLANG
Apparently Healthy, yet Diagnosed with Alzheimer’s?
It’s like this, fam. Some folks out here thinking they all good, right? But now, they talking ’bout diagnosing them with Alzheimer’s even if they ain’t showing no symptoms. 🧠
Usually, figuring out if somebody got Alzheimer’s takes a minute. You gotta sit down with the doc, run through your medical history, talk ’bout what’s been going on, and do some tests to see how your brain working.
Sometimes, they gotta hit you up with a PET scan, MRI, or even a spinal tap to see if you got these two proteins in your brain – amyloid plaques and tau tangles – which they say got something to do with Alzheimer’s.
Now, if this new gang of docs from the Alzheimer’s Association get their way, they wanna switch up the game. They talking ’bout using a blood test to peep if you got amyloid. And guess what? Some clinics and doctors already doing this kinda test.
Dr. Clifford R. Jack Jr., the head of this crew, saying, “If you got that amyloid in your brain, you got the disease, even if you ain’t showing no symptoms yet. The science don’t lie.”
But not everybody feeling this idea of just relying on these biomarker tests. The American Geriatrics Society saying it’s too early for all that and pointing out how some of these doctors got ties to them big pharma companies, raising questions ’bout conflicts of interest and all that.
They only just started talking ’bout this after five years ’cause two big things went down. First, they found out these amyloid blood tests are pretty accurate, less hassle than getting a spinal tap, and cheaper than getting your whole brain scanned. Plus, they got these new drugs like aducanumab and lecanemab getting the green light, even though it caused a whole lot of drama.
Now, they asking if it’s cool to diagnose healthy folks with Alzheimer’s just ’cause of a blood test that shows amyloid. Seems like some doctors already getting these requests.
But we can’t be sure how many of these folks with amyloid in their brain gonna end up with dementia. We need more research before we can say for sure.
For now, a lot of doctors saying these new rules ain’t ready for prime time. But one thing’s clear: if this change happens, it could mean a whole new wave of Alzheimer’s cases hitting the streets. 🧬🚫
NOW IN ENGLISH
Apparently Healthy, yet Diagnosed with Alzheimer’s?
Many people believe they are fine, but according to new standards, you can diagnose them with Alzheimer’s even if they don’t show symptoms. 🧠
The diagnosis of Alzheimer’s disease usually involves a lengthy process. A doctor collects the person’s medical history, discusses symptoms, and administers verbal and visual cognitive tests.
In some cases, they may undergo a PET scan, MRI, or spinal tap to check for two proteins in the brain – amyloid plaques and tau tangles – which are linked to Alzheimer’s.
All of this could change significantly if new standards proposed by the Alzheimer’s Association working group are widely adopted.
Their draft guidelines, Revised Criteria for Diagnosis and Staging of Alzheimer’s Disease, call for a simpler approach. This could mean a blood test to indicate the presence of amyloid. Some clinics and doctor’s offices are already using this type of test.
“Someone who has biomarker evidence of amyloid in the brain has the disease, whether they’re symptomatic or not,” said Dr. Clifford R. Jack Jr., the chair of the working group. “The pathology exists for years before symptom onset. That’s the science. It’s irrefutable.”
But many people still argue against the idea of relying solely on biomarkers. The American Geriatrics Society has called the proposed criteria “premature” and has noted the high proportion of panel members with ties to the pharmaceutical and biotechnology industries, which could cause conflicts of interest.
They only started addressing this issue five years after issuing the last guidelines for diagnosis because two major events forced them to make changes. 🔄
First, the amyloid blood tests proved to be highly accurate, less invasive than spinal taps, and far less expensive than brain scans. Plus, some drugs that remove amyloid from the brain, like aducanumab (brand name: Aduhelm) and lecanemab (Leqembi), received regulatory approval, although this caused a lot of controversy.
Are these changes enough reason to diagnose healthy people with an irreversible disease based on a blood test that can detect amyloid? It seems like some doctors are already receiving such requests.
But it’s hard to know how many of those with amyloid in the brain will eventually get dementia. Only further research will provide better answers to this issue.
For now, many doctors argue that the proposed guidelines still need a lot of work before they can be put into practice. But one thing is for sure, if this change happens, it could lead to a new kind of pandemic of Alzheimer’s disease. 🧬🚫
